Kata Kunci

Abstrak

The neutrophil-to-lymphocyte ratio (NLR) is the ratio between the number of neutrophils and lymphocytes in the peripheral blood. Neutrophils are responsible for an initial immune response to pathogens that enter the body through mechanisms such as chemotaxis, phagocytosis, the release of reactive oxygen species (ROS), granular proteins, and the production and release of cytokines. Neutrophils also play an important role in the occurrence of the systemic inflammatory response syndrome (SIRS). Several dermatological diseases are related to NLR, which is associated with the presence of an inflammatory process. NLR is considered an easy, inexpensive, and reproducible parameter that correlates with clinical outcomes and disease severity. Diseases in dermatology found to be associated with NLR include leprosy, Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), psoriasis, vitiligo, atopic dermatitis, systemic sclerosis, and skin cancer. In recent years, NLR has increasingly been established as an independent prognostic factor for neoplasms and as an inflammatory biomarker in various acute and chronic diseases in the dermatology field. However, not all studies have found significant results. For instance, the role of NLR in vitiligo remains controversial. This literature review will discuss specifics related to several dermatological diseases associated with NLR.